The chance of cheating is always there, but I find it too unlikely for me to worry about it too much. In a poker tournament, when one player is all in and two other players are active in. Just like in live poker, but for online: same stuff goes. Collusion is two or more players acting with a secret, common strategy. I guess all you can do is pick a site/table/poker room or whatever that you are fairly comfortable with.
I feel okay at homegames where I know everyone well (as they are all really honest players) or even casinos because of all the cameras, but you have to realize that stuff is only in place because cheaters have tried. In games like high/low a strong, undetectable. If anything, I think live games are more likely for cheating than online. The peek is a powerful tool for crooked card players and can be used to steer valuable cards to one’s own hand or damaging cards to an opponent. I've never cheated myself, but I am humble enough to realize it could easily happen to anyone. Same goes for cheating in live poker I think I do magic as a hobby - especially card magic there are a lot of techniques that cheaters could use in a live setting and the average player probably won't pick up on it. It is like getting pickpocketed you don't want it to happen to anyone, but the most susceptible ones are the ones who are too arrogant to realize it could happen to them. I'm not too worried cheating can happen in a live setting too.